Rat protein kinase N1 ELISA Kit | PKN1 elisa kit
Rat Serine/threonine-protein kinase N1, PKN1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
displays phosphorylation dependent protein kinase activity [RGD, Feb 2006]
Uniprot Description
PKN1: an AGC kinase of the PKN family. A PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcriptional regulation. Regulates the cytoskeletal network by phosphorylating intermediate filament proteins such as VIM and NFH, NFL and NFM, inhibiting their polymerization. Phosphorylates Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of H3T11, a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3K9me by JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, impairing their import in the nucleus. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by CASP3 cleavage during apoptosis. Localization to endosomes is mediated via its interaction with RHOB. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. Three isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.13; AGC group; PKN family
Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; midbody; nucleus; endosome; cleavage furrow
Molecular Function: protein serine/threonine kinase activity; protein kinase C activity; protein kinase C binding; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; histone binding; histone deacetylase binding; Rac GTPase binding; GTP-Rho binding; chromatin binding; ATP binding; protein kinase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; spleen development; hyperosmotic response; renal system process; negative regulation of protein amino acid phosphorylation; transcription, DNA-dependent; B cell homeostasis; regulation of immunoglobulin production; B cell apoptosis; negative regulation of protein kinase activity; negative regulation of B cell proliferation; signal transduction; protein amino acid phosphorylation; regulation of germinal center formation
Research Articles on PKN1
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Product Notes
The Rat PKN1 pkn1 (Catalog #AAA9331394) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331394 ELISA Kit recognizes Rat PKN1. It is sometimes possible for the material contained within the vial of "protein kinase N1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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