Mouse polycystic kidney disease 1 (autosomal dominant) ELISA Kit | PKD1 elisa kit
Mouse Polycystin-1, PKD1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PKD1: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion- channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. Defects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1). ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000. Belongs to the polycystin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: Golgi apparatus; cell surface; basolateral plasma membrane; integral to membrane; cytosol; cilium; cell projection; membrane; cytoplasm; plasma membrane; motile primary cilium; nucleus; lateral plasma membrane
Molecular Function: protein domain specific binding; protein binding; calcium channel activity; cation channel activity; carbohydrate binding; protein kinase binding
Biological Process: regulation of cell adhesion; blood vessel development; embryonic placenta development; cytoplasmic sequestering of transcription factor; positive regulation of protein binding; in utero embryonic development; heart development; detection of mechanical stimulus; liver development; JAK-STAT cascade; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; nitrogen compound metabolic process; cell-cell adhesion; peptidyl-serine phosphorylation; elevation of cytosolic calcium ion concentration; branching morphogenesis of a tube; establishment of cell polarity; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; protein export from nucleus; kidney development; cell cycle arrest; cartilage condensation
Research Articles on PKD1
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Product Notes
The Mouse PKD1 pkd1 (Catalog #AAA9324920) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324920 ELISA Kit recognizes Mouse PKD1. It is sometimes possible for the material contained within the vial of "polycystic kidney disease 1 (autosomal dominant), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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