Mouse piwi-like 4 (Drosophila) ELISA Kit | PIWIL4 elisa kit
Mouse Piwi-like protein 4, PIWIL4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PIWIL4: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci. Belongs to the argonaute family. Piwi subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; nucleic acid binding; RNA binding
Biological Process: regulation of translation; meiotic cell cycle; multicellular organismal development; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; cell differentiation
Research Articles on PIWIL4
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Product Notes
The Mouse PIWIL4 piwil4 (Catalog #AAA9316381) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316381 ELISA Kit recognizes Mouse PIWIL4. It is sometimes possible for the material contained within the vial of "piwi-like 4 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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