Pig phosphoinositide-3-kinase, catalytic, gamma polypeptide ELISA Kit | PIK3CG elisa kit

Pig Phosphatidylinositol-4, 5-bisphosphate 3-kinase Catalytic subunit gamma isoform, PIK3CG ELISA Kit

Cat. Num. AAA9316314

• Gene Names: PIK3CG; p120-PI3K
• Reactivity: Pig
• Synonyms: phosphoinositide-3-kinase; catalytic; gamma polypeptide; Pig Phosphatidylinositol-4; 5-bisphosphate 3-kinase Catalytic subunit gamma isoform; PIK3CG ELISA Kit; 5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG) ELISA kit; PI3CG; PI3K; PI3Kgamma; PIK3; 1-phosphatidylinositol 3-kinase; PI3-kinase; PTDINS-3-kinase; p110-gamma; phosphatidylinositol 3 kinase gamma; p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gam; PIK3CG elisa kit

• Reactivity: Pig

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 47522612
• NCBI GeneID: 396979
• NCBI Accession #: NP_999104.1
• NCBI GenBank Nucleotide #: NM_213939.1
• UniProt Accession #: O02697
• Molecular Weight: 126,658 Da
• NCBI Official Full Name: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
• NCBI Official Symbol: PIK3CG
• NCBI Official Synonym Symbols: p120-PI3K
• NCBI Protein Information: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; PI3Kgamma; p110gamma; PI3K-gamma; PI3-kinase subunit gamma; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; serine/threonine protein kinase PIK3CG; catalytic subunit of G-beta-gamma-activated; phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
• UniProt Protein Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
• Protein Family: Phosphatidylinositol 4,5-bisphosphate 3-kinase
• UniProt Gene Name: PIK3CG
• UniProt Synonym Gene Names: PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma
• UniProt Entry Name: PK3CG_PIG

Uniprot Description

Function: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Required for B-lymphocyte development and signaling. Together with other PI3Ks are involved in the oxidative burst produced by neutrophils in response to chemotactic agents. Together with PIK3CD regulate neutrophil extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to ADRBK1 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contribute to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis

Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.

Enzyme regulation: Activated by both the alpha and the beta-gamma G proteins following stimulation of G protein-coupled receptors (GPCRs). Activation by GPCRs is assisted by the regulatory subunits (PIK3R5 or PIK3R6) leading to the translocation from the cytosol to the plasma membrane and to kinase activation. When bound to PIK3R5 the PI3K activity of PIK3CG could be activated greater than 100-fold by the beta-gamma G proteins.