Pigeon WD Repeat Domain Phosphoinositide-Interacting Protein 1 (WIPI1) ELISA Kit | WIPI1 elisa kit

Pigeon WD Repeat Domain Phosphoinositide-Interacting Protein 1 (WIPI1) ELISA Kit

• Gene Names: WIPI1; ATG18; ATG18A; WIPI49
• Reactivity: Pigeon
• Synonyms: WD Repeat Domain Phosphoinositide-Interacting Protein 1 (WIPI1); Pigeon WD Repeat Domain Phosphoinositide-Interacting Protein 1 (WIPI1) ELISA Kit; WIPI1 elisa kit

• Reactivity: Pigeon

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 157388939
• NCBI GeneID: 55062
• NCBI Accession #: NP_060453.3
• NCBI GenBank Nucleotide #: NM_017983.7
• UniProt Accession #: Q5MNZ9; Q8IXM5; Q9NWF8
• Molecular Weight: 48,202 Da
• NCBI Official Full Name: WD repeat domain phosphoinositide-interacting protein 1 isoform a
• NCBI Official Synonym Full Names: WD repeat domain, phosphoinositide interacting 1
• NCBI Official Symbol: WIPI1
• NCBI Official Synonym Symbols: ATG18; ATG18A; WIPI49
• NCBI Protein Information: WD repeat domain phosphoinositide-interacting protein 1
• UniProt Protein Name: WD repeat domain phosphoinositide-interacting protein 1
• Protein Family: WD repeat domain phosphoinositide-interacting protein
• UniProt Gene Name: WIPI1
• UniProt Synonym Gene Names: WIPI49; WIPI-1; WIPI 49 kDa

NCBI Description

This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy (PubMed:28561066). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes (PubMed:28561066). There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:28561066). Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.