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Pigeon Tyrosine-Protein Phosphatase Non-Receptor Type 2 (PTPN2) ELISA Kit | PTPN2 elisa kit

Pigeon Tyrosine-Protein Phosphatase Non-Receptor Type 2 (PTPN2) ELISA Kit

Gene Names
Ptpn2; Ptpt; TC-PTP; AI325124
Reactivity
Pigeon
Synonyms
Tyrosine-Protein Phosphatase Non-Receptor Type 2 (PTPN2); Pigeon Tyrosine-Protein Phosphatase Non-Receptor Type 2 (PTPN2) ELISA Kit; PTPN2 elisa kit
Ordering
Reactivity
Pigeon
Preparation and Storage
Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
44,573 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 2 isoform b
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 2
NCBI Official Symbol
Ptpn2
NCBI Official Synonym Symbols
Ptpt; TC-PTP; AI325124
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 2
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 2
UniProt Gene Name
Ptpn2
UniProt Synonym Gene Names
Ptpt; Protein-tyrosine phosphatase PTP-2

Uniprot Description

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.

Research Articles on PTPN2

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Product Notes

The Pigeon PTPN2 ptpn2 (Catalog #AAA9910893) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9910893 ELISA Kit recognizes Pigeon PTPN2. It is sometimes possible for the material contained within the vial of "Tyrosine-Protein Phosphatase Non-Receptor Type 2 (PTPN2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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