Pigeon Protein Phosphatase 1 Regulatory Subunit 15B (PPP1R15B) ELISA Kit | PPP1R15B elisa kit
Pigeon Protein Phosphatase 1 Regulatory Subunit 15B (PPP1R15B) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
Uniprot Description
PPP1R15B: Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: protein phosphatase type 1 complex
Molecular Function: protein binding
Biological Process: negative regulation of protein amino acid phosphorylation
Disease: Microcephaly, Short Stature, And Impaired Glucose Metabolism 2
Research Articles on PPP1R15B
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Product Notes
The Pigeon PPP1R15B ppp1r15b (Catalog #AAA9394330) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9394330 ELISA Kit recognizes Pigeon PPP1R15B. It is sometimes possible for the material contained within the vial of "Protein Phosphatase 1 Regulatory Subunit 15B (PPP1R15B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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