Pigeon Paraplegin (SPG7) ELISA Kit | SPG7 elisa kit
Pigeon Paraplegin (SPG7) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SPG7: Putative ATP-dependent zinc metalloprotease. Defects in SPG7 are the cause of spastic paraplegia autosomal recessive type 7 (SPG7). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG7 is a complex form. Additional clinical features are cerebellar syndrome, supranuclear palsy, and cognitive impairment, particularly disturbance of attention and executive functions. Defects in SPG7 may cause autosomal recessive osteogenesis imperfecta (OI). Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass. Clinical features of SPG7-related osteogenesis imperfecta include recurrent fractures, mild bone deformities, delayed tooth eruption, normal hearing and white sclera. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Chaperone; EC 3.4.24.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: mitochondrion
Molecular Function: ATP-dependent peptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; unfolded protein binding
Biological Process: cell adhesion; mitochondrion organization and biogenesis; nervous system development
Disease: Spastic Paraplegia 7, Autosomal Recessive
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Product Notes
The Pigeon SPG7 spg7 (Catalog #AAA9394850) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9394850 ELISA Kit recognizes Pigeon SPG7. It is sometimes possible for the material contained within the vial of "Paraplegin (SPG7), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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