Pigeon Inositol Polyphosphate 5-Phosphatase OCRL-1 (OCRL) ELISA Kit | OCRL elisa kit
Pigeon Inositol Polyphosphate 5-Phosphatase OCRL-1 (OCRL) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Description
OCRL: Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; early endosome; early endosome membrane; Golgi stack; Golgi-associated vesicle; nucleus; phagocytic vesicle membrane; photoreceptor outer segment; plasma membrane; trans-Golgi network
Molecular Function: GTPase activator activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding; Rac GTPase binding
Biological Process: in utero embryonic development; inositol phosphate metabolic process; lipid metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of GTPase activity; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Disease: Dent Disease 2; Lowe Oculocerebrorenal Syndrome
Research Articles on OCRL
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Product Notes
The Pigeon OCRL ocrl (Catalog #AAA9396950) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9396950 ELISA Kit recognizes Pigeon OCRL. It is sometimes possible for the material contained within the vial of "Inositol Polyphosphate 5-Phosphatase OCRL-1 (OCRL), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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