Pigeon Heart- and Neural Crest Derivatives-Expressed Protein 2 (HAND2) ELISA Kit | HAND2 elisa kit
Pigeon Heart- and Neural Crest Derivatives-Expressed Protein 2 (HAND2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]
Uniprot Description
HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q33
Cellular Component: nuclear chromatin; protein complex; transcription factor complex
Molecular Function: AT DNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription coactivator activity; transcription factor binding
Biological Process: adult heart development; angiogenesis; apoptosis; embryonic digit morphogenesis; heart development; heart looping; heart morphogenesis; in utero embryonic development; mesenchymal cell proliferation; negative regulation of DNA binding; negative regulation of osteoblast differentiation; negative regulation of transcription factor activity; neural crest cell development; odontogenesis of dentine-containing teeth; palate development; peripheral nervous system neuron development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; suckling behavior; sympathetic nervous system development; thymus development; tongue development; transcription from RNA polymerase II promoter
Research Articles on HAND2
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Product Notes
The Pigeon HAND2 hand2 (Catalog #AAA9348287) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9348287 ELISA Kit recognizes Pigeon HAND2. It is sometimes possible for the material contained within the vial of "Heart- and Neural Crest Derivatives-Expressed Protein 2 (HAND2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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