Pigeon E3 SUMO-Protein Ligase PIAS4 (PIAS4) ELISA Kit | PIAS4 elisa kit

Pigeon E3 SUMO-Protein Ligase PIAS4 (PIAS4) ELISA Kit

• Gene Names: PIAS4; PIASY; Piasg; ZMIZ6; PIAS-gamma
• Reactivity: Pigeon
• Synonyms: E3 SUMO-Protein Ligase PIAS4 (PIAS4); Pigeon E3 SUMO-Protein Ligase PIAS4 (PIAS4) ELISA Kit; PIAS4 elisa kit

• Reactivity: Pigeon
• Sequence Length: 510

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 24850133
• NCBI GeneID: 51588
• NCBI Accession #: NP_056981.2
• NCBI GenBank Nucleotide #: NM_015897.3
• UniProt Accession #: Q8N2W9; O75926; Q96G19; Q9UN16
• Molecular Weight: 56,504 Da
• NCBI Official Full Name: E3 SUMO-protein ligase PIAS4
• NCBI Official Synonym Full Names: protein inhibitor of activated STAT 4
• NCBI Official Symbol: PIAS4
• NCBI Official Synonym Symbols: PIASY; Piasg; ZMIZ6; PIAS-gamma
• NCBI Protein Information: E3 SUMO-protein ligase PIAS4
• UniProt Protein Name: E3 SUMO-protein ligase PIAS4
• Protein Family: E3 SUMO-protein ligase
• UniProt Gene Name: PIAS4
• UniProt Synonym Gene Names: PIASG; PIAS-gamma

Uniprot Description

PIAS4: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Interacts with AR, AXIN1, GATA2, LEF1, TP53 and STAT1 (IFNG-induced). Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Interacts with TICAM1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes. Belongs to the PIAS family.

Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nuclear matrix; nucleoplasm; nucleus; PML body; transferase complex

Molecular Function: DNA binding; protein binding; protein C-terminus binding; SUMO transferase activity; transcription corepressor activity; ubiquitin protein ligase binding; zinc ion binding

Biological Process: double-strand break repair via nonhomologous end joining; negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of keratinocyte apoptotic process; positive regulation of protein sumoylation; protein sumoylation; transcription, DNA-dependent; Wnt signaling pathway