E3 SUMO-protein ligase PIAS4 (PIAS4) Recombinant Protein | PIAS4 recombinant protein
Recombinant Human E3 SUMO-protein ligase PIAS4 (PIAS4)
Gene Names
PIAS4; PIASY; Piasg; ZMIZ6; PIAS-gamma
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
E3 SUMO-protein ligase PIAS4 (PIAS4); Recombinant Human E3 SUMO-protein ligase PIAS4 (PIAS4); PIAS4 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-510, Full length protein
Sequence
AAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSECEDADEIEYLVDGSWCPIRAEKERSCSPQGAILVLGPSDANGLLPAPSVNGSGALGSTGGGGPVGSMENGKPGADVVDLTLDSSSSSEDEEEEEEEEEDEDEEGPRPKRRCPFQKGLVPAC
Sequence Length
509
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
56,504 Da
NCBI Official Full Name
E3 SUMO-protein ligase PIAS4
NCBI Official Synonym Full Names
protein inhibitor of activated STAT 4
NCBI Official Symbol
PIAS4
NCBI Official Synonym Symbols
PIASY; Piasg; ZMIZ6; PIAS-gamma
NCBI Protein Information
E3 SUMO-protein ligase PIAS4
UniProt Protein Name
E3 SUMO-protein ligase PIAS4
Protein Family
UniProt Gene Name
PIAS4
UniProt Synonym Gene Names
PIASG; PIAS-gamma
Uniprot Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Research Articles on PIAS4
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Product Notes
The PIAS4 pias4 (Catalog #AAA1330884) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-510, Full length protein. The amino acid sequence is listed below: AAELVEAKNM VMSFRVSDLQ MLLGFVGRSK SGLKHELVTR ALQLVQFDCS PELFKKIKEL YETRYAKKNS EPAPQPHRPL DPLTMHSTYD RAGAVPRTPL AGPNIDYPVL YGKYLNGLGR LPAKTLKPEV RLVKLPFFNM LDELLKPTEL VPQNNEKLQE SPCIFALTPR QVELIRNSRE LQPGVKAVQV VLRICYSDTS CPQEDQYPPN IAVKVNHSYC SVPGYYPSNK PGVEPKRPCR PINLTHLMYL SSATNRITVT WGNYGKSYSV ALYLVRQLTS SELLQRLKTI GVKHPELCKA LVKEKLRLDP DSEIATTGVR VSLICPLVKM RLSVPCRAET CAHLQCFDAV FYLQMNEKKP TWMCPVCDKP APYDQLIIDG LLSKILSECE DADEIEYLVD GSWCPIRAEK ERSCSPQGAI LVLGPSDANG LLPAPSVNGS GALGSTGGGG PVGSMENGKP GADVVDLTLD SSSSSEDEEE EEEEEEDEDE EGPRPKRRCP FQKGLVPAC. It is sometimes possible for the material contained within the vial of "E3 SUMO-protein ligase PIAS4 (PIAS4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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