Period circadian protein (per) Recombinant Protein | per recombinant protein

Recombinant Drosophila melanogaster Period circadian protein (per), partial

• Gene Names: per; CG2647; Clk; clk-6; DmelCG2647; dmper; dper; dPER; EG:155E2.4; mel_per; Per; PER
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Period circadian protein (per); Recombinant Drosophila melanogaster Period circadian protein (per); partial; per recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,067

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 442614977
• NCBI GeneID: 31251
• NCBI Accession #: NP_001259194.1
• NCBI GenBank Nucleotide #: NM_001272265.1
• UniProt Accession #: P07663; O17483; O76882; O76883; O76884; O76885; Q24446; Q24447; Q24448; Q24449; Q6PVA3; Q8MLY0
• Molecular Weight: 112,804 Da
• NCBI Official Full Name: period, isoform B
• NCBI Official Synonym Full Names: period
• NCBI Official Symbol: per
• NCBI Official Synonym Symbols: CG2647; Clk; clk-6; DmelCG2647; dmper; dper; dPER; EG:155E2.4; mel_per; Per; PER
• NCBI Protein Information: CG2647 gene product from transcript CG2647-RA
• UniProt Protein Name: Period circadian protein
• Protein Family: Period circadian protein
• UniProt Gene Name: per
• UniProt Synonym Gene Names: CLK-6

Uniprot Description

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).