Sushi Peptide S3, aa268-301 Peptide
Sushi Peptide S3, aa268-301 (Factor C Sushi 3)
Purity
95.04%. Purified by HPLC
Synonyms
Sushi Peptide S3; aa268-301; aa268-301 (Factor C Sushi 3); aa268-301 peptide
Host
Synthetic peptide
Purity/Purification
95.04%. Purified by HPLC
Form/Format
Supplied as a lyophilized powder
Sequence
H-His-Ala-Glu-His-Lys-Val-Lys-Ile-Gly-Val-Glu-Gln-Lys-Tyr-Gly-Gln-Phe-Pro-Gln-Gly-Thr-Glu-Val-Thr-Tyr-Thr-Cys-Ser-Gly-Asn-Tyr-Phe-Leu-Met-OH
Molecular Formula
C175H261N45O52S2
Grade
Highly Purified
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Sushi Peptide S3, aa268-301 peptide
N-HAEHKVKIGVEQKYGQFPQGTEVTYTCSGNYFLM-C (linear), corresponds to residues 268 to 301 of the factor C Sushi 3 domain and is designated S3, with an MW of 3,892.
Factor C protein isolated from the horseshoe crab, Carcinoscorpius rotundicauda, has endotoxin binding capability. Synthetic peptides of 34 amino acids based on the sequence of two regions of factor C (Sushi 1 and Sushi 3) as well as their corresponding mutants exhibited activities against 30 clinical isolates of Pseudomonas aeruginosa. Collectively, all four peptides demonstrated exceptionally effective bactericidal activity against P. aeruginosa with 90% minimal bactericidal concentrations (MBC90s) in the range of 0.06 to 0.25ug/ml (16 to 63nM). Viable bacteria were reduced by 90% after 7 min and were totally eradicated within 40 to 50 min. These peptides are minimally hemolytic against both rabbit and human erythrocytes even at concentrations up to 1,600-fold their MBC90s. Both in vitro and in vivo studies indicate that cytotoxic effects are small even at 1,000-fold their MBC90s. Furthermore, the Sushi peptides are tolerant of high-salt and adverse pH conditions. These findings demonstrate the promising therapeutic potential of the Sushi peptides.
Factor C protein isolated from the horseshoe crab, Carcinoscorpius rotundicauda, has endotoxin binding capability. Synthetic peptides of 34 amino acids based on the sequence of two regions of factor C (Sushi 1 and Sushi 3) as well as their corresponding mutants exhibited activities against 30 clinical isolates of Pseudomonas aeruginosa. Collectively, all four peptides demonstrated exceptionally effective bactericidal activity against P. aeruginosa with 90% minimal bactericidal concentrations (MBC90s) in the range of 0.06 to 0.25ug/ml (16 to 63nM). Viable bacteria were reduced by 90% after 7 min and were totally eradicated within 40 to 50 min. These peptides are minimally hemolytic against both rabbit and human erythrocytes even at concentrations up to 1,600-fold their MBC90s. Both in vitro and in vivo studies indicate that cytotoxic effects are small even at 1,000-fold their MBC90s. Furthermore, the Sushi peptides are tolerant of high-salt and adverse pH conditions. These findings demonstrate the promising therapeutic potential of the Sushi peptides.
Product Categories/Family for Sushi Peptide S3, aa268-301 peptide
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Product Notes
The Sushi Peptide S3, aa268-301 (Catalog #AAA634019) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: H-His-Ala- Glu-His-Ly s-Val-Lys- Ile-Gly-Va l-Glu-Gln- Lys-Tyr-Gl y-Gln-Phe- Pro-Gln-Gl y-Thr-Glu- Val-Thr-Ty r-Thr-Cys- Ser-Gly-As n-Tyr-Phe- Leu-Met-OH. It is sometimes possible for the material contained within the vial of "Sushi Peptide S3, aa268-301, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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