Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) Recombinant Protein | PELP1 recombinant protein

Recombinant Human Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) , partial

• Gene Names: PELP1; MNAR; P160
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Proline-; glutamic acid- and leucine-rich protein 1 (PELP1); Recombinant Human Proline-; partial; PELP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,130

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 503774456
• NCBI GeneID: 27043
• NCBI Accession #: NP_001265170.1
• NCBI GenBank Nucleotide #: NM_001278241.1
• UniProt Accession #: Q8IZL8; O15450; Q5EGN3; Q6NTE6; Q96FT1; Q9BU60
• Molecular Weight: 119,700 Da
• NCBI Official Full Name: proline-, glutamic acid- and leucine-rich protein 1 isoform 2
• NCBI Official Synonym Full Names: proline, glutamate and leucine rich protein 1
• NCBI Official Symbol: PELP1
• NCBI Official Synonym Symbols: MNAR; P160
• NCBI Protein Information: proline-, glutamic acid- and leucine-rich protein 1
• UniProt Protein Name: Proline-, glutamic acid- and leucine-rich protein 1
• Protein Family: Proline-, glutamic acid- and leucine-rich protein
• UniProt Gene Name: PELP1
• UniProt Synonym Gene Names: HMX3; MNAR

NCBI Description

This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Description

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).