PEA-15 recombinant protein

PEA-15, 1-130aa, Human, E Coli

Cat. Num. AAA203400

• Gene Names: PEA15; PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: PEA-15; 1-130aa; Human; E Coli; Phosphoprotein enriched in astrocytes 15kD; Astrocytic phosphoprotein PEA-15; PEA15; PED; Phosphoprotein enriched in astrocytes; 15kD Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HuMMAT 1H; HuMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; PEA15 protein; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in diabetes.; PEA-15 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
• Sequence Length: 130

• Applicable Applications for PEA-15 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for PEA-15 recombinant protein

Phospho-enriched protein in astrocytes 15 kDa (PEA-15) is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes. This protein has been implicated in the regulation of multiple cellular processes including apoptosis, proliferation, glucose transport, adhesion and migration. Increased PEA-15 levels may affect tumorigenesis and cancer progression, thus it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. Recombinant human PEA-15 was expressed in E Coli and purified by using conventional chromatography.

Product Categories/Family for PEA-15 recombinant protein

Neuroscience

References

Beguinot F., et al. (2009) Am J Physiol Endocrinol Metab. 297 (3):E592-601.; ueno NT., et al. (2008) Cancer Res. 68 (22):9302-10.;

NCBI and Uniprot Product Information

• NCBI GI #: 4505705
• NCBI GeneID: 8682
• NCBI Accession #: NP_003759
• NCBI GenBank Nucleotide #: NM_003768.4
• UniProt Accession #: Q15121; O00511; B1AKZ3
• Molecular Weight: 15 kDa (130aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: astrocytic phosphoprotein PEA-15 isoform b
• NCBI Official Synonym Full Names: proliferation and apoptosis adaptor protein 15
• NCBI Official Symbol: PEA15
• NCBI Official Synonym Symbols: PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H; PED-PEA15; PED/PEA15
• NCBI Protein Information: astrocytic phosphoprotein PEA-15
• UniProt Protein Name: Astrocytic phosphoprotein PEA-15
• UniProt Gene Name: PEA15
• UniProt Synonym Gene Names: PED

NCBI Description

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.