Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1) Recombinant Protein | Pdzk1 recombinant protein

Recombinant Rat Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1)

Cat. Num. AAA1388124

• Gene Names: Pdzk1; Clamp
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1); Recombinant Rat Na (+)/H (+) exchange regulatory cofactor NHE-RF3 (Pdzk1); Pdzk1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-523, full length protein
• Sequence: MASTFNPRECKLSKKEGQNYGFFLRIEKDTDGHLVRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVDLVRKSGNSVTLLVLDGDSYEKAVKHQVDLKELDQSPREPALNEKKPDLGMNGGVETCAQPRLCYLVKEGNSFGFSLKTIQGKKGVFLTDITPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTPFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGESVEALDHDGVVEMIRNGGDQTTLLVLDKEADRIYSLARFSPLLYCQSQELPNGSVKEAPAPISAPLEAPGSATTEDVGDHKPKLCRLIKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDIIIEVNGENVQDEPYDRVVERIKSSGEHVTLLVCGKVAYSYFQAKKIPILSSLADPLVAGPDAKGETEHDSAESTKDSSHPARDRTLSAASHSSSNSEDTVM
• Sequence Length: 523

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 13928998
• NCBI GeneID: 65144
• NCBI Accession #: NP_113900.1
• NCBI GenBank Nucleotide #: NM_031712.1
• UniProt Accession #: Q9JJ40; O35234; Q6AZ21
• Molecular Weight: 56,800 Da
• NCBI Official Full Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• NCBI Official Synonym Full Names: PDZ domain containing 1
• NCBI Official Symbol: Pdzk1
• NCBI Official Synonym Symbols: Clamp
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: Pdzk1
• UniProt Synonym Gene Names: Clamp; Diphor1; Nherf3; NHERF-3; NaPi-Cap1

NCBI Description

binds the N-terminal PDZ domain of scavenger receptor class B type I; may play a role in intracellular transport of cholesterol esters [RGD, Feb 2006]

Uniprot Description

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (). Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons.