Human PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) ELISA Kit | PDS5B elisa kit

Human Sister chromatid cohesion protein PDS5 homolog B, PDS5B ELISA Kit

Cat. Num. AAA9325203

• Gene Names: PDS5B; AS3; APRIN; CG008
• Reactivity: Human
• Synonyms: PDS5; regulator of cohesion maintenance; homolog B (S. cerevisiae); Human Sister chromatid cohesion protein PDS5 homolog B; PDS5B ELISA Kit; Human Sister chromatid cohesion protein PDS5 homolog B (PDS5B) ELISA kit; APRIN; AS3; CG008; FLJ23236; KIAA0979; RP1-267P19.1; Alpha-1; 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein LOC641515; homolog B; ; PDS5B elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Serum, Plasma and Tissue Homogenate
• Assay Type: Sandwich
• Detection Range: 0.625ng/ml-20ng/ml.
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for PDS5B elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of PDS5B (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

NCBI and Uniprot Product Information

• NCBI GI #: 7657269
• NCBI GeneID: 23047
• NCBI Accession #: NP_055847.1
• NCBI GenBank Nucleotide #: NM_015032.3
• UniProt Accession #: Q9NTI5; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9Y2I5; Q9Y451
• Molecular Weight: 164,667 Da
• NCBI Official Full Name: sister chromatid cohesion protein PDS5 homolog B
• NCBI Official Synonym Full Names: PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
• NCBI Official Symbol: PDS5B
• NCBI Official Synonym Symbols: AS3; APRIN; CG008
• NCBI Protein Information: sister chromatid cohesion protein PDS5 homolog B; androgen-induced shutoff 3; androgen-induced proliferation inhibitor; androgen induced inhibitor of proliferation; androgen-induced prostate proliferative shutoff-associated protein AS3
• UniProt Protein Name: Sister chromatid cohesion protein PDS5 homolog B
• Protein Family: Sister chromatid cohesion protein
• UniProt Gene Name: PDS5B
• UniProt Synonym Gene Names: APRIN; AS3; KIAA0979
• UniProt Entry Name: PDS5B_HUMAN

NCBI Description

This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]

Uniprot Description

APRIN: a widely expressed nuclear protein. Is lost in many cancers and may function as a tumor suppressor. Correlates with differentiation in embryonal carcinoma stem cells; its knockdown disrupted Nanog, Oct4, and SOX2 regulation. Plays a role in androgen-induced proliferative arrest in prostate cells. Is upregulated in androgen-sensitive LNCaP prostate cancer cells undergoing androgen-induced proliferative block. Required for maintenance of sister chromatid cohesion during mitosis. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Phosphorylated upon DNA damage. Maximum levels occur 18-20 hours after androgen exposure. Interacts with the cohesin complex. Phosphorylated upon DNA damage, probably by ATM or ATR. Five isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; chromosome; chromatin; cytosol; nucleus; chromosome, pericentric region

Molecular Function: protein binding; DNA binding; ATP binding

Biological Process: negative regulation of cell proliferation; cell proliferation; cell division; mitotic sister chromatid cohesion; mitotic cell cycle; regulation of cell proliferation