Programmed cell death protein 6 Recombinant Protein | PDCD6 recombinant protein

Recombinant Human Programmed cell death protein 6

Cat. Num. AAA9421690

• Gene Names: PDCD6; ALG2; ALG-2; PEF1B
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Programmed cell death protein 6; Recombinant Human Programmed cell death protein 6; Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2; PDCD6 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-191aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for PDCD6 recombinant protein

Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Ses to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca2+ affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.

NCBI and Uniprot Product Information

• NCBI GI #: 389565483
• NCBI GeneID: 10016
• NCBI Accession #: NP_001254485.1
• NCBI GenBank Nucleotide #: NM_001267556.1
• UniProt Accession #: O75340; Q2YDC2; Q5TZS0; B2RD16; E7ESR3
• Molecular Weight: 49.3kD
• NCBI Official Full Name: programmed cell death protein 6 isoform 2
• NCBI Official Synonym Full Names: programmed cell death 6
• NCBI Official Symbol: PDCD6
• NCBI Official Synonym Symbols: ALG2; ALG-2; PEF1B
• NCBI Protein Information: programmed cell death protein 6
• UniProt Protein Name: Programmed cell death protein 6
• Protein Family: Programmed cell death protein
• UniProt Gene Name: PDCD6
• UniProt Synonym Gene Names: ALG-2

NCBI Description

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Uniprot Description

PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: COPII vesicle coat; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; nucleus

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; magnesium ion binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity; protein homodimerization activity

Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; neural crest cell development; neural crest formation; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; response to calcium ion