Mouse pre-B-cell leukemia homeobox 1 ELISA Kit | PBX1 elisa kit

Mouse Pre-B-cell leukemia transcription factor 1, PBX1 ELISA Kit

Cat. Num. AAA9334170

• Gene Names: Pbx1; Pbx-1; 2310056B04Rik; D230003C07Rik
• Reactivity: Mouse
• Synonyms: pre-B-cell leukemia homeobox 1; Mouse Pre-B-cell leukemia transcription factor 1; PBX1 ELISA Kit; Mouse Pre-B-cell leukemia transcription factor 1 (PBX1) ELISA kit; DKFZp686B09108; MGC126627; Pre-B cell leukemia transcription factor-1; pre-B-cell leukemia transcription factor 1; PBX1 elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
• Assay Type: Sandwich
• Detection Range: 62.5 pg/ml - 2000 pg/ml.
• Sensitivity: 10 pg/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for PBX1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of PBX1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 614458205
• NCBI GeneID: 18514
• NCBI Accession #: NP_001278437.1
• NCBI GenBank Nucleotide #: NM_001291508.1
• UniProt Accession #: P41778
• Molecular Weight: 46,626 Da
• NCBI Official Full Name: pre-B-cell leukemia transcription factor 1 isoform b
• NCBI Official Synonym Full Names: pre B cell leukemia homeobox 1
• NCBI Official Symbol: Pbx1
• NCBI Official Synonym Symbols: Pbx-1; 2310056B04Rik; D230003C07Rik
• NCBI Protein Information: pre-B-cell leukemia transcription factor 1; homeobox protein PBX1
• UniProt Protein Name: Pre-B-cell leukemia transcription factor 1
• Protein Family: Pre-B-cell leukemia transcription factor
• UniProt Gene Name: Pbx1
• UniProt Synonym Gene Names: Pbx-1
• UniProt Entry Name: PBX1_MOUSE

NCBI Description

This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

PBX1: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. Expressed in all tissues except in cells of the B and T lineage. Belongs to the TALE/PBX homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Oncoprotein; DNA-binding; Transcription factor

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; embryonic skeletal development; multicellular organismal development; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; cell differentiation; proximal/distal pattern formation; embryonic limb morphogenesis; spleen development; transcription, DNA-dependent; thymus development; embryonic hemopoiesis; adrenal gland development; negative regulation of transcription factor activity; regulation of cell proliferation; negative regulation of neuron differentiation; organ morphogenesis; ureteric bud branching; embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; regulation of ossification; sex differentiation; steroid biosynthetic process; urogenital system development