Human Prostatic Binding Protein ELISA Kit | PBP elisa kit

Human Prostatic Binding Protein ELISA Kit

Cat. Num. AAA36841

• Gene Names: PEBP1; PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34
• Reactivity: Human
• Synonyms: Prostatic Binding Protein; Human Prostatic Binding Protein ELISA Kit; PBP elisa kit

• Reactivity: Human
• Sequence Length: 187

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4505621
• NCBI GeneID: 5037
• NCBI Accession #: NP_002558.1
• NCBI GenBank Nucleotide #: NM_002567.2
• UniProt Accession #: P30086; B2R4S1
• Molecular Weight: 21,057 Da
• NCBI Official Full Name: phosphatidylethanolamine-binding protein 1 preproprotein
• NCBI Official Synonym Full Names: phosphatidylethanolamine binding protein 1
• NCBI Official Symbol: PEBP1
• NCBI Official Synonym Symbols: PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34
• NCBI Protein Information: phosphatidylethanolamine-binding protein 1; neuropolypeptide h3; prostatic binding protein; prostatic-binding protein; raf kinase inhibitor protein; Raf kinase inhibitory protein; epididymis luminal protein 210; epididymis secretory protein Li 34; hippocampal cholinergic neurostimulating peptide
• UniProt Protein Name: Phosphatidylethanolamine-binding protein 1
• Protein Family: Pheromone-binding protein
• UniProt Gene Name: PEBP1
• UniProt Synonym Gene Names: PBP; PEBP; PEBP-1; RKIP; HCNP
• UniProt Entry Name: PEBP1_HUMAN

NCBI Description

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

Uniprot Description

RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice.

Protein type: Lipid-binding; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 12q24.23

Cellular Component: cytoplasm; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; phosphatidylethanolamine binding; protein kinase binding; ATP binding