C12orf48 Blocking Peptide | PARPBP blocking peptide
C12orf48 Antibody (C-term) Blocking peptide
Gene Names
PARPBP; AROM; PARI; C12orf48
Synonyms
C12orf48; C12orf48 Antibody (C-term) Blocking peptide; PCNA-interacting partner; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP; PARPBP blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
579
Cellular Location
Cytoplasm. Nucleus Note: Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA
Tissue Location
Restricted to testis. Overexpressed in multiple cancer cells.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PARPBP blocking peptide
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,399 Da
NCBI Official Full Name
PCNA-interacting partner isoform 2
NCBI Official Synonym Full Names
PARP1 binding protein
NCBI Official Symbol
PARPBP
NCBI Official Synonym Symbols
AROM; PARI; C12orf48
NCBI Protein Information
PCNA-interacting partner
UniProt Protein Name
PCNA-interacting partner
Protein Family
UniProt Gene Name
PARPBP
UniProt Synonym Gene Names
C12orf48; PARI; PARI; PARPBP
UniProt Entry Name
PARI_HUMAN
Uniprot Description
PARPBP: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect. Belongs to the PARI family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component: chromatin; nucleoplasm
Molecular Function: protein binding
Research Articles on PARPBP
Similar Products
Product Notes
The PARPBP parpbp (Catalog #AAA9217408) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "C12orf48, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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