Minor vault p193 Recombinant Protein | PARP4 recombinant protein

Minor vault p193 protein (human), (recombinant) (His-tag)

Cat. Num. AAA566084

• Gene Names: PARP4; PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1
• Purity: >=98%
• Synonyms: Minor vault p193; Minor vault p193 protein (human); (recombinant) (His-tag); PARP4 recombinant protein

• Host: E Coli
• Purity/Purification: >=98%
• Form/Format: Liquid. In 20mM HEPES, pH7.0, containing 140mM KCl, 5mM sodium chloride and 50% glycerol
• Concentration: 0.2mg/ml (varies by lot)

• Source Note: Catalytic domain of human minor vault p193 protein (aa 220-574) is fused at the C-terminus to a His-tag
• Preparation and Storage: For long term storage, store at -80 degree C. Avoid freeze/thaw cycles; Shipping: Shipped on Dry Ice

Related Product Information for PARP4 recombinant protein

Vault poly(ADP-ribose) polymerase (VPARP; PARP-4) was originally identified as a minor protein component of the vault ribonucleoprotein particle. Vaults have been implicated in multidrug resistance of human tumors and are thought to be involved in macromolecular assembly and/or transport. In addition to the association of VPARP with the cytoplasmic vault particle, subpopulations of VPARP localize to the nucleus and the mitotic spindle, indicating that VPARP may have other cellular functions. VPARP has been shown to associate with telomerase activity and interact with exogenously expressed telomerase-associated protein 1 (TEP1) in mammalian cells.

Product Categories/Family for PARP4 recombinant protein

Cellular Analysis; DNA Regulation & Transcription; Metabolism; Multidrug Resistance

NCBI and Uniprot Product Information

• NCBI GI #: 112789550
• NCBI GeneID: 143
• NCBI Accession #: NP_006428.2
• NCBI GenBank Nucleotide #: NM_006437.3
• UniProt Accession #: Q9UKK3; O75903; Q14682; Q5QNZ9; Q9H1M6
• Molecular Weight: 192,595 Da
• NCBI Official Full Name: poly
• NCBI Official Synonym Full Names: poly (ADP-ribose) polymerase family, member 4
• NCBI Official Symbol: PARP4
• NCBI Official Synonym Symbols: PH5P; p193; ARTD4; PARPL; VPARP; VWA5C; PARP-4; VAULT3; ADPRTL1
• NCBI Protein Information: poly [ADP-ribose] polymerase 4; poly [ADP-ribose] polymerase 4; PARP-related; H5 proline-rich; I-alpha-I-related; 193 kDa vault protein; vault protein, 193-kDa; poly(ADP-ribose) synthetase; vault poly(ADP-ribose) polymerase; poly(ADP-ribosyl)transferase-l
• UniProt Protein Name: Poly [ADP-ribose] polymerase 4
• Protein Family: Poly [ADP-ribose] polymerase
• UniProt Gene Name: PARP4
• UniProt Synonym Gene Names: ADPRTL1; KIAA0177; PARPL; PARP-4; ARTD4; PH5P; VPARP
• UniProt Entry Name: PARP4_HUMAN

NCBI Description

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]

Uniprot Description

PARP4: Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to MVP. Associates with TEP1.

Protein type: EC 2.4.2.30; Transferase

Chromosomal Location of Human Ortholog: 13q11

Cellular Component: membrane; spindle microtubule; cytoplasm; ribonucleoprotein complex; nucleus

Molecular Function: protein binding; enzyme binding; DNA binding; NAD+ ADP-ribosyltransferase activity

Biological Process: cell death; response to drug; protein amino acid ADP-ribosylation; transport; protein modification process; inflammatory response; DNA repair; response to DNA damage stimulus