Protein DJ-1 (PARK7), partial Recombinant Protein | PARK7 recombinant protein

Recombinant Mesocricetus auratus Protein DJ-1 (PARK7), partial

• Gene Names: Park7; cap1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein DJ-1 (PARK7); partial; Recombinant Mesocricetus auratus Protein DJ-1 (PARK7); Protein DJ-1; EC=3.4.-.-; Contraception-associated protein 1; Parkinson disease protein 7 homolog; PARK7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)

• Species: Mesocricetus auratus (Golden hamster)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 528078163
• NCBI GeneID: 101826467
• NCBI Accession #: NP_001268568.1
• NCBI GenBank Nucleotide #: NM_001281639.1
• UniProt Accession #: Q7TQ35
• Molecular Weight: 19,915 Da
• NCBI Official Full Name: protein DJ-1
• NCBI Official Symbol: Park7
• NCBI Official Synonym Symbols: cap1
• NCBI Protein Information: protein DJ-1; Contraception-associated protein 1; Parkinson disease protein 7 homolog
• UniProt Protein Name: Protein DJ-1
• Protein Family: Protein deglycase
• UniProt Gene Name: PARK7
• UniProt Synonym Gene Names: CAP1
• UniProt Entry Name: PARK7_MESAU

Uniprot Description

Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity.