Human Pregnancy Associated Plasma Protein A ELISA Kit | PAPP-A elisa kit

Human Pregnancy Associated Plasma Protein A ELISA Kit

Cat. Num. AAA26323

• Gene Names: PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• Reactivity: Human
• Synonyms: Pregnancy Associated Plasma Protein A; Human Pregnancy Associated Plasma Protein A ELISA Kit; PAPP-A elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.
• Sequence Length: 1627

• Samples: Porcine Body Fluids, Tissue Homogenates, Secretions Or Feces Samples
• Assay Type: Quantitative Sandwich
• Detection Range: 62.5 pg/ml-2000 pg/ml
• Sensitivity: 10 pg/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for PAPP-A elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of PAOX (hereafter termed "analyte") in undiluted original Porcine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 223590248
• NCBI GeneID: 5069
• UniProt Accession #: Q13219; Q08371; Q68G52; Q9UDK7; B1AMF9
• Molecular Weight: 180,973 Da
• NCBI Official Full Name: Pappalysin-1
• NCBI Official Synonym Full Names: pregnancy-associated plasma protein A, pappalysin 1
• NCBI Official Symbol: PAPPA
• NCBI Official Synonym Symbols: PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
• NCBI Protein Information: pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; pregnacy-associated plasma protein A; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease
• UniProt Protein Name: Pappalysin-1
• UniProt Gene Name: PAPPA
• UniProt Synonym Gene Names: IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A
• UniProt Entry Name: PAPP1_HUMAN

NCBI Description

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

Uniprot Description

PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.

Protein type: Secreted; EC 3.4.24.79; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: membrane; extracellular region

Molecular Function: metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: cellular protein metabolic process; female pregnancy; proteolysis; cell differentiation