PADI2 recombinant protein

Recombinant Human PADI2 protein, N- TwinStrep Tag

Cat. Num. AAA157377

• Gene Names: PADI2; PAD2; PDI2; PAD-H19
• Purity: >90% as determined by SDS-PAGE
• Synonyms: PADI2; Recombinant Human PADI2 protein; N- TwinStrep Tag; KIAA0994; PAD2; PDI2; PADI2 recombinant protein

• Host: Baculovirus-Insect cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the human PADI2 (Met1~Pro665) was fused with the N-terminal TwinStrep Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

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Product Categories/Family for PADI2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 16307225
• NCBI GeneID: 11240
• UniProt Accession #: Q9Y2J8; Q9UPN2
• Molecular Weight: 75,564 Da
• NCBI Official Full Name: PADI2 protein
• NCBI Official Synonym Full Names: peptidyl arginine deiminase, type II
• NCBI Official Symbol: PADI2
• NCBI Official Synonym Symbols: PAD2; PDI2; PAD-H19
• NCBI Protein Information: protein-arginine deiminase type-2; protein-arginine deiminase type II
• UniProt Protein Name: Protein-arginine deiminase type-2
• Protein Family: Protein-arginine deiminase
• UniProt Gene Name: PADI2
• UniProt Synonym Gene Names: KIAA0994; PDI2
• UniProt Entry Name: PADI2_HUMAN

NCBI Description

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Uniprot Description

PADI2: Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family.

Protein type: EC 3.5.3.15; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytoplasm

Molecular Function: estrogen receptor binding; calcium ion binding; protein-arginine deiminase activity

Biological Process: substantia nigra development; estrogen receptor signaling pathway; chromatin-mediated maintenance of transcription; peptidyl-citrulline biosynthetic process from peptidyl-arginine