p16 INK4 alpha recombinant protein
p16 INK4 alpha protein
Applications
User optimized
Purity
> 95% by SDS PAGE and HPLC analysis.
Synonyms
p16 INK4 alpha; p16 INK4 alpha protein; p INK4 alpha 16 protein; p INK4 alpha-16; p16-INK4 protein; Cyclin-dependent kinase inhibitor 2A protein; MTS-1 protein; p16INK4A protein; Cyclin-dependent kinase 4 inhibitor A protein; p16 INK-4 alpha protein; p INK4 alpha-16 protein; p INK4 alpha 16; CDK4I protein; Multiple tumor suppressor 1 protein; p16 INK4 alpha recombinant protein
Host
Escherichia Coli.
Purity/Purification
> 95% by SDS PAGE and HPLC analysis.
Form/Format
Lyophilized from 1x PBS+1.0 mM DTT, pH 7.2. Sterile filter though a 0.2 micron filter. Reconstitute in 1 x PBS, pH 8.0 to a concentration of 0.1-1.0 mg/ml.
Sequence
Region of p16 INK4 alpha protein corresponding to amino acids MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD.
Applicable Applications for p16 INK4 alpha recombinant protein
User optimized
Protein Type
Recombinant
Biological Significance
p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer.
Contaminants
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Biohazard
Not for human use. Use normal laboratory precautions when handling reagent. For research purposes only.
Grade
Recombinant Human
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at 4°C short term, -20°C for long term. For extended storage after reconstituted, dilute in a buffer containing a carrier protein, aliquot and store at -20°C to -80°C . Avoid repeat freeze-thaws.
Related Product Information for p16 INK4 alpha recombinant protein
Purified recombinant Human p16 INK4 alpha protein
Product Categories/Family for p16 INK4 alpha recombinant protein
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Product Notes
The p16 INK4 alpha (Catalog #AAA539490) is a Recombinant Protein produced from Escherichia Coli. and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's p16 INK4 alpha can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the p16 INK4 alpha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of p16 INK4 alpha protein correspond ing to amino acids MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD. It is sometimes possible for the material contained within the vial of "p16 INK4 alpha, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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