Guinea Pig Phospho-Glycogen Synthase Kinase 3beta ELISA Kit | P-GSK3beta elisa kit
Guinea pig Phospho-Glycogen Synthase Kinase 3beta ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: protein complex; endoplasmic reticulum; integral to plasma membrane; plasma membrane; intercellular junction; lipid raft
Molecular Function: protein binding
Biological Process: actin cytoskeleton reorganization; excretion
Disease: Nephrotic Syndrome, Type 2
Research Articles on P-GSK3beta
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Product Notes
The Guinea Pig P-GSK3beta nphs2 (Catalog #AAA730112) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA730112 ELISA Kit recognizes Guinea Pig P-GSK3beta. It is sometimes possible for the material contained within the vial of "Phospho-Glycogen Synthase Kinase 3beta, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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