Transcription factor Ovo-like 2 (OVOL2) Recombinant Protein | OVOL2 recombinant protein

Recombinant Human Transcription factor Ovo-like 2 (OVOL2)

Cat. Num. AAA1424765

• Gene Names: OVOL2; CHED; CHED1; CHED2; PPCD1; ZNF339; EUROIMAGE566589
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transcription factor Ovo-like 2 (OVOL2); Recombinant Human Transcription factor Ovo-like 2 (OVOL2); OVOL2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-275, Full length protein
• Sequence: MPKVFLVKRRSLGVSVRSWDELPDEKRADTYIPVGLGRLLHDPPEDCRSDGGSSSGSGSSSAGEPGGAESSSSPHAPESETPEPGDAEGPDGHLATKQRPVARSKIKFTTGTCSDSVVHSCDLCGKGFRLQRMLNRHLKCHNQVKRHLCTFCGKGFNDTFDLKRHVRTHTGIRPYKCNVCNKAFTQRCSLESHLKKIHGVQQQYAYKQRRDKLYVCEDCGYTGPTQEDLYLHVNSAHPGSSFLKKTSKKLAALLQGKLTSAHQENTSLSEEEERK
• Sequence Length: 275

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 743405586
• NCBI GeneID: 58495
• NCBI Accession #: NP_001290390.1
• NCBI GenBank Nucleotide #: NM_001303461.1
• UniProt Accession #: Q9BRP0; Q5T8B4; Q9BX22; Q9HA54; Q9Y4M0
• Molecular Weight: 16,565 Da
• NCBI Official Full Name: transcription factor Ovo-like 2 isoform 2
• NCBI Official Synonym Full Names: ovo like zinc finger 2
• NCBI Official Symbol: OVOL2
• NCBI Official Synonym Symbols: CHED; CHED1; CHED2; PPCD1; ZNF339; EUROIMAGE566589
• NCBI Protein Information: transcription factor Ovo-like 2
• UniProt Protein Name: Transcription factor Ovo-like 2
• Protein Family: Transcription factor
• UniProt Gene Name: OVOL2
• UniProt Synonym Gene Names: ZNF339; hOvo2

NCBI Description

This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

Uniprot Description

Zinc-finger transcription repressor factor (PubMed:19700410). Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer (). Positively regulates neuronal differentiation (). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (PubMed:19700410). Important for the correct development of primordial germ cells in embryos ().