OTU domain-containing protein 7B (OTUD7B) Recombinant Protein | OTUD7B recombinant protein

Recombinant Human OTU domain-containing protein 7B (OTUD7B) , partial

• Gene Names: OTUD7B; ZA20D1; CEZANNE
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: OTU domain-containing protein 7B (OTUD7B); Recombinant Human OTU domain-containing protein 7B (OTUD7B); partial; OTUD7B recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 814

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 118026942
• NCBI GeneID: 56957
• NCBI Accession #: NP_064590.2
• NCBI GenBank Nucleotide #: NM_020205.3
• UniProt Accession #: Q6GQQ9; Q5SZ60; Q8WWA7; Q9NQ53; Q9UFF4; B7Z643; D3DUZ8
• Molecular Weight: 88,947 Da
• NCBI Official Full Name: OTU domain-containing protein 7B
• NCBI Official Synonym Full Names: OTU deubiquitinase 7B
• NCBI Official Symbol: OTUD7B
• NCBI Official Synonym Symbols: ZA20D1; CEZANNE
• NCBI Protein Information: OTU domain-containing protein 7B
• UniProt Protein Name: OTU domain-containing protein 7B
• Protein Family: OTU domain-containing protein
• UniProt Gene Name: OTUD7B
• UniProt Synonym Gene Names: ZA20D1; Cezanne

Uniprot Description

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.