Osteopetrosis Associated Transmembrane Protein 1 Recombinant Protein | OSTM1 recombinant protein

Recombinant Osteopetrosis Associated Transmembrane Protein 1 (OSTM1)

Cat. Num. AAA2034119

• Gene Names: OSTM1; GL; GIPN; OPTB5; HSPC019
• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >90%
• Synonyms: Osteopetrosis Associated Transmembrane Protein 1; Recombinant Osteopetrosis Associated Transmembrane Protein 1 (OSTM1); GL; GIPN; Chloride channel 7 beta subunit; OSTM1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >90%
• Sequence Length: 56

• Applicable Applications for OSTM1 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Gln120~Gly251
• Tag: Two N-terminal Tags, His-tag and T7-tag
• Expression System: Prokaryotic Expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 955475220
• NCBI GeneID: 28962
• Molecular Weight: 18.6kDa
• NCBI Official Full Name: osteopetrosis associated transmembrane protein 1, partial
• NCBI Official Synonym Full Names: osteopetrosis associated transmembrane protein 1
• NCBI Official Symbol: OSTM1
• NCBI Official Synonym Symbols: GL; GIPN; OPTB5; HSPC019
• NCBI Protein Information: osteopetrosis-associated transmembrane protein 1
• UniProt Protein Name: Osteopetrosis-associated transmembrane protein 1
• Protein Family: Osteopetrosis-associated transmembrane protein
• UniProt Gene Name: OSTM1
• UniProt Synonym Gene Names: GL
• UniProt Entry Name: OSTM1_HUMAN

NCBI Description

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]

Uniprot Description

OSTM1: Required for osteoclast and melanocyte maturation and function. Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5); also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.

Protein type: Membrane protein, integral; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytoplasm; cytosol; integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; nucleus

Biological Process: osteoclast differentiation; transmembrane transport

Disease: Osteopetrosis, Autosomal Recessive 5