Odorant receptor 47a (Or47a) Recombinant Protein | Or47a recombinant protein
Recombinant Drosophila melanogaster Odorant receptor 47a (Or47a)
NCBI and Uniprot Product Information
Uniprot Description
Function: Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Ref.6 Ref.7 Ref.8
Subunit structure: Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway. Ref.6 Ref.7 Ref.8
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Expressed with Orco in 40 olfactory receptor neurons in a broad area across the antenna, including both anterior and posterior faces. This expression pattern matches the distribution of the small sensilla basiconica. Expression in the antenna is observed late in antennal development at 93 hours APF. Ref.5 Ref.6
Miscellaneous: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities: Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]
Research Articles on Or47a
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Product Notes
The Or47a or47a (Catalog #AAA1226253) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-385. The amino acid sequence is listed below: MDSFLQVQKS TIALLGFDLF SENREMWKRP YRAMNVFSIA AIFPFILAAV LHNWKNVLLL ADAMVALLIT ILGLFKFSMI LYLRRDFKRL IDKFRLLMSN EAEQGEEYAE ILNAANKQDQ RMCTLFRTCF LLAWALNSVL PLVRMGLSYW LAGHAEPELP FPCLFPWNIH IIRNYVLSFI WSAFASTGVV LPAVSLDTIF CSFTSNLCAF FKIAQYKVVR FKGGSLKESQ ATLNKVFALY QTSLDMCNDL NQCYQPIICA QFFISSLQLC MLGYLFSITF AQTEGVYYAS FIATIIIQAY IYCYCGENLK TESASFEWAI YDSPWHESLG AGGASTSICR SLLISMMRAH RGFRITGYFF EANMEAFSSI VRTAMSYITM LRSFS. It is sometimes possible for the material contained within the vial of "Odorant receptor 47a (Or47a), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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