Oxidized low-density lipoprotein receptor 1 (OLR1) Recombinant Protein | OLR1 recombinant protein

Recombinant Pig Oxidized low-density lipoprotein receptor 1 (OLR1), partial

Cat. Num. AAA1479992

• Gene Names: OLR1; OLR-1; CLEC8A; PLOX-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Oxidized low-density lipoprotein receptor 1 (OLR1); Recombinant Pig Oxidized low-density lipoprotein receptor 1 (OLR1); partial; OLR1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 61-274
• Sequence: SQVSDLLKQQ KVKLTHQEDI LEGQALAQRQ AEKSSQESQR ELTEMIETLA HKLDEKSKKL MELQQQNLNL QKALEKAANF SGPCPQDWLW HEENCYKFSS GPFSWEKSRE NCLSLDAQLL KINSTDDLEF IQQTIAHSSF PFWMGLSLRK PNNSWLWEDG TPLMPHLFRL QGAASQMYPS GTCAYIHRGI VFAENCILNA FSICQKRANL LRAQ
• Sequence Length: 214

• Species: Sus scrofa (Pig)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for OLR1 recombinant protein

This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer s disease. Alternative transcript variants have been described but their full-length sequence has not been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 47523234
• NCBI GeneID: 396724
• NCBI Accession #: NP_998970.1
• NCBI GenBank Nucleotide #: NM_213805.1
• UniProt Accession #: Q9TTK7
• Molecular Weight: 31,143 Da
• NCBI Official Full Name: oxidized low-density lipoprotein receptor 1
• NCBI Official Symbol: OLR1
• NCBI Official Synonym Symbols: OLR-1; CLEC8A; PLOX-1
• NCBI Protein Information: oxidized low-density lipoprotein receptor 1
• UniProt Protein Name: Oxidized low-density lipoprotein receptor 1
• Protein Family: Oxidized low-density lipoprotein receptor
• UniProt Gene Name: OLR1
• UniProt Synonym Gene Names: LOX1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1

Uniprot Description

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria ().