Rat Obscurin ELISA Kit | OBSCN elisa kit

Rat Obscurin (OBSCN) ELISA Kit

Gene Names

OBSCN; UNC89; ARHGEF30

Reactivity

Rat

Synonyms

Obscurin; Rat Obscurin (OBSCN) ELISA Kit; OBSCN elisa kit

Ordering
Cat. Num. AAA2606385 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Rat

Sequence Length

6620

Preparation and Storage

Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

NCBI GI #

15026974

NCBI GeneID

84033

UniProt Accession #

Q5VST9; Q2A664; Q5T7G8; Q5T7G9; Q5VSU2; Q86YC7; Q8NHN0; Q8NHN1; Q8NHN2; Q8NHN3; Q8NHN4; Q8NHN5

Molecular Weight

924,971 Da

NCBI Official Full Name

obscurin

NCBI Official Synonym Full Names

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

NCBI Official Symbol

OBSCN

NCBI Official Synonym Symbols

UNC89; ARHGEF30

NCBI Protein Information

obscurin

UniProt Protein Name

Obscurin

Protein Family

Obscurin

UniProt Gene Name

OBSCN

UniProt Synonym Gene Names

KIAA1556; KIAA1639; Obscurin-MLCK

UniProt Entry Name

OBSCN_HUMAN

NCBI Description

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; CAMK group; Trio family

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cytosol; M band; myofibril; Z disc

Molecular Function: ankyrin binding; ATP binding; calmodulin binding; metal ion binding; protein binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; titin binding

Biological Process: multicellular organismal development; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sarcomere organization; small GTPase mediated signal transduction

Research Articles on OBSCN

1. Findings indicate that loss of giant obscurins from breast epithelium results in disruption of the cell-cell contacts and acquisition of a mesenchymal phenotype that leads to enhanced tumorigenesis, migration and invasiveness in vitro and in vivo.

Similar Products

Product Notes

The Rat OBSCN obscn (Catalog #AAA2606385) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2606385 ELISA Kit recognizes Rat OBSCN. It is sometimes possible for the material contained within the vial of "Obscurin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...