Nuclear pore complex protein Nup153 Recombinant Protein | NU153 recombinant protein

Recombinant Human Nuclear pore complex protein Nup153

Cat. Num. AAA9420506

• Gene Names: NUP153; N153; HNUP153
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Nuclear pore complex protein Nup153; Recombinant Human Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153; NU153 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of Zinc finger 657-880aa, 657-880aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for NU153 recombinant protein

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding elent in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport elent (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear mbrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore mbrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

NCBI and Uniprot Product Information

• NCBI GI #: 503774352
• NCBI GeneID: 9972
• NCBI Accession #: NP_001265138.1
• NCBI GenBank Nucleotide #: NM_001278209.1
• UniProt Accession #: P49790; Q4LE47; Q5T9I7; Q7Z743; B4DIK2; E7EPX5; F6QR24
• Molecular Weight: 27.4kD
• NCBI Official Full Name: nuclear pore complex protein Nup153 isoform 1
• NCBI Official Synonym Full Names: nucleoporin 153
• NCBI Official Symbol: NUP153
• NCBI Official Synonym Symbols: N153; HNUP153
• NCBI Protein Information: nuclear pore complex protein Nup153
• UniProt Protein Name: Nuclear pore complex protein Nup153
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP153

NCBI Description

Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Uniprot Description

NUP153: Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.

Protein type: Nuclear export; Nucleoporin

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytosol; nuclear inclusion body; nuclear membrane; nuclear pore; nucleolus; nucleoplasm

Molecular Function: identical protein binding; nuclear localization sequence binding; nucleocytoplasmic transporter activity; protein anchor; protein binding; structural constituent of nuclear pore

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; negative regulation of RNA export from nucleus; nuclear pore complex assembly; protein import into nucleus; protein sumoylation; tRNA export from nucleus; viral reproduction; viral transcription