BDNF/NT-3 growth factors receptor (NTRK2) Recombinant Protein | NTRK2 recombinant protein

Recombinant Chicken BDNF/NT-3 growth factors receptor (NTRK2), partial

Cat. Num. AAA1376356

• Gene Names: NTRK2; TRKB
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: BDNF/NT-3 growth factors receptor (NTRK2); Recombinant Chicken BDNF/NT-3 growth factors receptor (NTRK2); partial; NTRK2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 32-426
• Sequence: CPASCRCSS WRIWCSEPVP GITSFPVPQR STEDDNVTEI YIANQRKLES INDNEVGFYV GLKNLTVVDS GLRFVSRQAF VKNINLQYIN LSRNKLSSLS KKPFRHLGLS DLILVDNPFK CSCEIMWIKK FQETKFYTEA QDIYCVDDNN KRIALMDMKV PNCDLPSANL SNYNITVVEG KSITLYCDTT GGPPPNVSWV LTNLVSNHES DTSKNPASLT IKNVSSMDSG LWISCVAENI VGEVQTSAEL TVFFAPNITF IESPTPDHHW CIPFTVKGNP KPTLQWFYEG AILNESEYIC TKIHVINQSE YHGCLQLDNP THLNNGAYTL LAKNEYGEDE KRVDAHFMSV PGDGSGPIVD PDVYEYETTP NDLGDTTNNS NQITSPDVSN KENEDS
• Sequence Length: 395

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for NTRK2 recombinant protein

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 45382555
• NCBI GeneID: 396157
• NCBI Accession #: NP_990562.1
• NCBI GenBank Nucleotide #: NM_205231.1
• UniProt Accession #: Q91987; Q91010
• Molecular Weight: 56,777 Da
• NCBI Official Full Name: BDNF/NT-3 growth factors receptor
• NCBI Official Synonym Full Names: neurotrophic receptor tyrosine kinase 2
• NCBI Official Symbol: NTRK2
• NCBI Official Synonym Symbols: TRKB
• NCBI Protein Information: BDNF/NT-3 growth factors receptor
• UniProt Protein Name: BDNF/NT-3 growth factors receptor
• Protein Family: BDNF/NT-3 growth factors receptor
• UniProt Gene Name: NTRK2
• UniProt Synonym Gene Names: TRKB; Trk-B

Uniprot Description

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signaling cascades. Activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Also regulates the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells.