E3 SUMO-protein ligase NSE2 (NSMCE2) Recombinant Protein | NSMCE2 recombinant protein
Recombinant Bovine E3 SUMO-protein ligase NSE2 (NSMCE2)
NCBI and Uniprot Product Information
Uniprot Description
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression ().
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Product Notes
The NSMCE2 nsmce2 (Catalog #AAA1460759) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-248, full length protein. The amino acid sequence is listed below: MPGRSTSSSS SGSTGFISFS GVESALSSLK TFQSCISSGM DTASSVALDL VETQTEVSSE YSMDKAMVEF AMMDRELNHY LKAVQSTINH VKEERSEKIP DLKLLVEKKF LALQNKNSDA DFQNNEKFVQ FKQQLKELKK QYGLQSDREA DITEGVDEDM IVTQSQTNFI CPITQLEMKK PVKNKVCGHT YEEEAIVRMI ESKHERKKKA CCPKIGCSHV DMRMSDLIQD EALRRAIESH KKRRRQSN. It is sometimes possible for the material contained within the vial of "E3 SUMO-protein ligase NSE2 (NSMCE2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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