Human non-SMC element 1 homolog (S. cerevisiae) ELISA Kit | NSMCE1 elisa kit
Human Non-structural maintenance of chromosomes element 1 homolog, NSMCE1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NSMCE1: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus. Belongs to the NSE1 family.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: nucleoplasm; chromosome, telomeric region; intracellular membrane-bound organelle; cytoplasm
Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: protein ubiquitination; DNA repair; DNA recombination
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Product Notes
The Human NSMCE1 nsmce1 (Catalog #AAA9332918) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332918 ELISA Kit recognizes Human NSMCE1. It is sometimes possible for the material contained within the vial of "non-SMC element 1 homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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