Mouse neural retina leucine zipper ELISA Kit | NRL elisa kit
Mouse Neural retina-specific leucine zipper protein, NRL ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Description
NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.
Protein type: DNA-binding; Transcription factor
Cellular Component: nucleus
Molecular Function: leucine zipper domain binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; retinal rod cell development; regulation of transcription, DNA-dependent; positive regulation of rhodopsin gene expression; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression
Research Articles on NRL
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Product Notes
The Mouse NRL nrl (Catalog #AAA9322921) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322921 ELISA Kit recognizes Mouse NRL. It is sometimes possible for the material contained within the vial of "neural retina leucine zipper, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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