Nuclear Factor Recombinant Protein | NFE2L2 recombinant protein

Recombinant Nuclear Factor, Erythroid Derived 2 Like Protein 2 (NFE2L2)

Cat. Num. AAA2034309

• Gene Names: NRIP1; RIP140
• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Nuclear Factor; Recombinant Nuclear Factor; Erythroid Derived 2 Like Protein 2 (NFE2L2); NRF2; HEBP1; NF-E2-Related Factor 2; Nuclear factor; erythroid derived 2; like 2; NFE2L2 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >95%
• Sequence Length: 1158

• Applicable Applications for NFE2L2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Ser400~Lys603
• Tag: Prokaryotic expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 7717256
• NCBI GeneID: 8204
• UniProt Accession #: P48552; Q8IWE8
• Molecular Weight: 53.5kDa
• NCBI Official Full Name: nuclear factor
• NCBI Official Synonym Full Names: nuclear receptor interacting protein 1
• NCBI Official Symbol: NRIP1
• NCBI Official Synonym Symbols: RIP140
• NCBI Protein Information: nuclear receptor-interacting protein 1
• UniProt Protein Name: Nuclear receptor-interacting protein 1
• Protein Family: Nuclear factor
• UniProt Gene Name: NRIP1
• UniProt Entry Name: NRIP1_HUMAN

NCBI Description

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

RIP140: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 21q11.2

Cellular Component: cell junction; histone deacetylase complex; nuclear chromatin; nuclear speck; nucleolus; nucleoplasm; nucleus

Molecular Function: androgen receptor binding; estrogen receptor binding; glucocorticoid receptor binding; histone deacetylase binding; nuclear hormone receptor binding; protein binding; retinoid X receptor binding; transcription coactivator activity; transcription corepressor activity

Biological Process: androgen receptor signaling pathway; circadian regulation of gene expression; circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle rupture; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequestering of lipid; transcription, DNA-dependent