CoupTFII/NR2F2 Recombinant Protein | CoupTFII recombinant protein

Human CoupTF2/NR2F2 (Fragment)

Cat. Num. AAA692543

• Gene Names: NR2F2; ARP1; ARP-1; CHTD4; NF-E3; SVP40; COUPTF2; COUPTFB; TFCOUP2; COUPTFII
• Reactivity: Human
• Synonyms: CoupTFII/NR2F2; Human CoupTF2/NR2F2 (Fragment); COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2; CoupTFII recombinant protein

• Host: E Coli
• Reactivity: Human
• Form/Format: Lyophilized
• Sequence: MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEL EHHHHHH
• Sequence Length: 197; Length [aa]

• Tag: His-Tag

Related Product Information for CoupTFII recombinant protein

Tumor growth depends on nutrients and oxygen supplied by the vasculature through angiogenesis. It was shown that the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), a member of the nuclear receptor family, is a major angiogenesis regulator within the tumor microenvironment. COUP-TFs consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). Conditional ablation of COUP-TFII in the tumor microenvironment severely compromised neoangiogenesis and lymphangiogenesis during pancreatic tumor progression and metastasis. It was shown that COUP-TFII plays a cell-autonomous role in endothelial cells to control blood vessel sprouting by regulating cell proliferation and migration. Mechanistic investigations revealed that COUP-TFII suppressed vascular endothelial growth factor receptor-2 (VEGFR-2/KDR) signaling by transcriptionally repressing the expression of VEGFR-1, thereby curtailing a central angiogenic driver of vascular growth. These results implicate COUP-TFII as a critical factor in tumor angiogenesis through regulation of VEGF/VEGFR-2 signaling, suggesting COUP-TFII as a candidate target for antiangiogenic therapy.

NCBI and Uniprot Product Information

• NCBI GI #: 223555949
• NCBI GeneID: 7026
• NCBI Accession #: NP_001138627.1
• NCBI GenBank Nucleotide #: NM_021005.3
• UniProt Accession #: P24468
• NCBI Official Full Name: COUP transcription factor 2 isoform b
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2 group F member 2
• NCBI Official Symbol: NR2F2
• NCBI Official Synonym Symbols: ARP1; ARP-1; CHTD4; NF-E3; SVP40; COUPTF2; COUPTFB; TFCOUP2; COUPTFII
• NCBI Protein Information: COUP transcription factor 2
• UniProt Protein Name: COUP transcription factor 2
• UniProt Gene Name: NR2F2
• UniProt Synonym Gene Names: ARP1; TFCOUP2; COUP-TF2; ARP-1; COUP-TF II
• UniProt Entry Name: COT2_HUMAN

NCBI Description

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription factor activity

Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; anterior/posterior pattern formation; regulation of transcription from RNA polymerase II promoter; fertilization; forebrain development; negative regulation of endothelial cell proliferation; blood vessel morphogenesis; steroid hormone mediated signaling; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation; maternal placenta development

Disease: Congenital Heart Defects, Multiple Types, 4