Mouse Natriuretic peptides A ELISA Kit | Nppa elisa kit

Mouse Natriuretic peptides A ELISA Kit

Cat. Num. AAA2885716

• Gene Names: Nppa; ANP; Anf; Pnd
• Reactivity: Mouse
• Synonyms: Natriuretic peptides A; Mouse Natriuretic peptides A ELISA Kit; Prepronatriodilatin; Nppa; Pnd; Nppa elisa kit

• Reactivity: Mouse
• Sequence Length: 152

• Assay Type: Sandwich
• Detection Range: 15.6-1000 pg/mL
• Sensitivity: 7.86 pg/mL
• Intra-Assay CV: <=6.8%
• Inter-Assay CV: <=9.3%
• Recovery: 98%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 59797056
• NCBI GeneID: 230899
• NCBI Accession #: NP_032751.1
• NCBI GenBank Nucleotide #: NM_008725.3
• UniProt Accession #: P05125; Q5FW59
• Molecular Weight: 16,572 Da
• NCBI Official Full Name: natriuretic peptides A preproprotein
• NCBI Official Synonym Full Names: natriuretic peptide type A
• NCBI Official Symbol: Nppa
• NCBI Official Synonym Symbols: ANP; Anf; Pnd
• NCBI Protein Information: natriuretic peptides A
• UniProt Protein Name: Natriuretic peptides A
• Protein Family: Natriuretic peptides
• UniProt Gene Name: Nppa
• UniProt Synonym Gene Names: Pnd; ANF; ANP
• UniProt Entry Name: ANF_MOUSE

NCBI Description

This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]

Uniprot Description

NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted, signal peptide; Secreted

Cellular Component: cytoplasm; extracellular region; extracellular space; mast cell granule; nucleus; perinuclear region of cytoplasm

Molecular Function: hormone activity; neuropeptide hormone activity; peptide hormone receptor binding; receptor binding

Biological Process: cardiac muscle hypertrophy; cGMP biosynthetic process; female pregnancy; negative regulation of cell growth; negative regulation of systemic arterial blood pressure; neuropeptide signaling pathway; positive regulation of heart rate; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel size