Sheep Niemann-Pick C1-Like Protein 1 ELISA Kit | NPC1L1 elisa kit

Sheep Niemann-Pick C1-Like Protein 1 ELISA Kit

Cat. Num. AAA7266339

• Gene Names: NPC1L1; LDLCQ7; NPC11L1; SLC65A2
• Reactivity: Sheep
• Synonyms: Niemann-Pick C1-Like Protein 1; Sheep Niemann-Pick C1-Like Protein 1 ELISA Kit; NPC1L1 elisa kit

• Reactivity: Sheep
• Sequence Length: 1359

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for NPC1L1 elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

Product Categories/Family for NPC1L1 elisa kit

Signal Transduction; Neuroscience; Cardiovascular; Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 6643036
• NCBI GeneID: 29881
• Molecular Weight: 145,794 Da
• NCBI Official Full Name: Niemann-Pick C1-like protein 1
• NCBI Official Synonym Full Names: NPC1 like intracellular cholesterol transporter 1
• NCBI Official Symbol: NPC1L1
• NCBI Official Synonym Symbols: LDLCQ7; NPC11L1; SLC65A2
• NCBI Protein Information: NPC1-like intracellular cholesterol transporter 1
• UniProt Protein Name: NPC1-like intracellular cholesterol transporter 1
• Protein Family: Niemann-Pick C1-like protein
• UniProt Gene Name: NPC1L1

NCBI Description

The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.