Guinea Pig Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 ELISA Kit | NOX4 elisa kit
Guinea pig Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Uniprot Description
NOX4: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Oxidoreductase; Membrane protein, integral; EC 1.6.3.-; Membrane protein, multi-pass; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q14.2-q21
Cellular Component: endoplasmic reticulum membrane; focal adhesion; mitochondrion; perinuclear region of cytoplasm; apical plasma membrane; nucleolus; stress fiber; integral to membrane; NADPH oxidase complex
Molecular Function: oxygen sensor activity; FAD binding; electron carrier activity; NAD(P)H oxidase activity; superoxide-generating NADPH oxidase activity; nucleotide binding; heme binding
Biological Process: positive regulation of apoptosis; cell morphogenesis; cell aging; homocysteine metabolic process; positive regulation of smooth muscle cell migration; cardiac muscle cell differentiation; negative regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; positive regulation of stress fiber formation; response to hypoxia; inflammatory response; superoxide release; bone resorption
Research Articles on NOX4
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Product Notes
The Guinea Pig NOX4 nox4 (Catalog #AAA726433) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA726433 ELISA Kit recognizes Guinea Pig NOX4. It is sometimes possible for the material contained within the vial of "Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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