Testing Data
(The OmniKine Human Notch-1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Notch-1 proteins within the range of 79-5000 pg/ml.)
Human Notch-1 ELISA Kit | NOTCH1 elisa kit
Notch-1 (Human) OmniKine ELISA Kit
Human: DLL1, DNER, Jagged 1/Fc Chimera, Jagged 2/Fc Chimera, Notch-2/Fc Chimera, Notch-3/Fc Chimera
Murine: Notch-1/Fc Chimera
Rat: Notch-1/Fc Chimera, Notch-2/Fc Chimera
Testing Data
(The OmniKine Human Notch-1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Notch-1 proteins within the range of 79-5000 pg/ml.)
Testing Data
(The OmniKine Human Notch-1 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Notch-1 proteins within the range of 79-5000 pg/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Uniprot Description
Notch 1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Heterodimer of a C-terminal fragment N(TM) and an N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Forms a trimeric complex with FBXW7 and SGK1. Interacts with HIF1AN. HIF1AN negatively regulates the function of notch intracellular domain (NICD), accelerating myogenic differentiation. In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Belongs to the NOTCH family.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: acrosomal vesicle; adherens junction; apical plasma membrane; cell surface; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; integral component of membrane; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function: calcium ion binding; chromatin DNA binding; DNA binding transcription factor activity; enzyme binding; enzyme inhibitor activity; Notch binding; protein binding; protein heterodimerization activity; sequence-specific DNA binding; transmembrane receptor activity
Biological Process: activation of Notch receptor target transcription factor; aortic valve morphogenesis; apoptotic process involved in embryonic digit morphogenesis; astrocyte differentiation; atrioventricular node development; atrioventricular valve morphogenesis; auditory receptor cell fate commitment; axonogenesis; branching morphogenesis of a tube; cardiac atrium morphogenesis; cardiac chamber formation; cardiac left ventricle morphogenesis; cardiac muscle cell proliferation; cardiac muscle morphogensis; cardiac right atrium morphogenesis; cardiac right ventricle formation; cardiac ventricle morphogenesis; cell cycle arrest; cell differentiation in spinal cord; cell fate specification; cell migration involved in endocardial cushion formation; cellular response to follicle-stimulating hormone stimulus; collecting duct development; compartment pattern specification; coronary vein morphogenesis; determination of left/right symmetry; distal tubule development; embryonic hindlimb morphogenesis; endocardial cushion morphogenesis; endocardium development; endocardium morphogenesis; endoderm development; epithelial to mesenchymal transition; epithelial to mesenchymal transition involved in endocardial cushion formation; forebrain development; foregut morphogenesis; glomerular mesangial cell development; growth involved in heart morphogenesis; hair follicle morphogenesis; heart development; heart looping; humoral immune response; immune response; in utero embryonic development; inflammatory response to antigenic stimulus; interleukin-4 secretion; keratinocyte differentiation; left/right axis specification; liver development; lumen formation; lung development; mesenchymal cell development; mitral valve formation; negative regulation of anoikis; negative regulation of auditory receptor cell differentiation; negative regulation of BMP signaling pathway; negative regulation of calcium ion-dependent exocytosis; negative regulation of canonical Wnt signaling pathway; negative regulation of catalytic activity; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of cell-substrate adhesion; negative regulation of endothelial cell chemotaxis; negative regulation of gene expression; negative regulation of growth rate; negative regulation of myoblast differentiation; negative regulation of myotube differentiation; negative regulation of neurogenesis; negative regulation of oligodendrocyte differentiation; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of photoreceptor cell differentiation; negative regulation of pro-B cell differentiation; negative regulation of stem cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural tube development; Notch signaling pathway; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; oligodendrocyte differentiation; organ regeneration; pericardium morphogenesis; positive regulation of aorta morphogenesis; positive regulation of apoptosis; positive regulation of astrocyte differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of JAK-STAT cascade; positive regulation of keratinocyte differentiation; positive regulation of neuroblast proliferation; positive regulation of Notch signaling pathway; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of viral genome replication; pulmonary valve morphogenesis; regulation of extracellular matrix assembly; regulation of somitogenesis; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; regulation of transcription, DNA-templated; response to corticosteroid stimulus; response to lipopolysaccharide; response to muramyl dipeptide; somatic stem cell division; spermatogenesis; sprouting angiogenesis; tissue regeneration; transcription initiation from RNA polymerase II promoter; ventricular trabecula myocardium morphogenesis
Disease: Adams-oliver Syndrome 5; Aortic Valve Disease 1
Research Articles on NOTCH1
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Product Notes
The Human NOTCH1 notch1 (Catalog #AAA9501982) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501982 ELISA Kit recognizes Human NOTCH1. It is sometimes possible for the material contained within the vial of "Notch-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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