Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2) Recombinant Protein | GLTSCR2 recombinant protein
Recombinant Human Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2)
NCBI and Uniprot Product Information
Uniprot Description
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1 (PubMed:27824081).
Research Articles on GLTSCR2
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Product Notes
The GLTSCR2 nop53 (Catalog #AAA1482351) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-478, Full length protein. The amino acid sequence is listed below: AAGGSGVGGK RSSKSDADSG FLGLRPTSVD PALRRRRRGP RNKKRGWRRL AQEPLGLEVD QFLEDVRLQE RTSGGLLSEA PNEKLFFVDT GSKEKGLTKK RTKVQKKSLL LKKPLRVDLI LENTSKVPAP KDVLAHQVPN AKKLRRKEQL WEKLAKQGEL PREVRRAQAR LLNPSATRAK PGPQDTVERP FYDLWASDNP LDRPLVGQDE FFLEQTKKKG VKRPARLHTK PSQAPAVEVA PAGASYNPSF EDHQTLLSAA HEVELQRQKE AEKLERQLAL PATEQAATQE STFQELCEGL LEESDGEGEP GQGEGPEAGD AEVCPTPARL ATTEKKTEQQ RRREKAVHRL RVQQAALRAA RLRHQELFRL RGIKAQVALR LAELARRQRR RQARREAEAD KPRRLGRLKY QAPDIDVQLS SELTDSLRTL KPEGNILRDR FKSFQRRNMI EPRERAKFKR KYKVKLVEKR AFREIQL. It is sometimes possible for the material contained within the vial of "Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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