NME6 recombinant protein

Recombinant Human NME6 protein

Cat. Num. AAA1562219

• Gene Names: NME6; NDK 6; NM23-H6; IPIA-ALPHA
• Purity: >90% as determined by SDS-PAGE
• Synonyms: NME6; Recombinant Human NME6 protein; Nucleoside diphosphate kinase 6; NDK 6; NDP kinase 6; Inhibitor of p53-induced apoptosis-alpha; IPIA-alpha; nm23-H6; NME6 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human NME6 (Leu11-Ala190) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for NME6 recombinant protein

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Product Categories/Family for NME6 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 5031951
• NCBI GeneID: 10201
• NCBI Accession #: NP_005784.1
• NCBI GenBank Nucleotide #: NM_005793.3
• UniProt Accession #: O75414; Q53HM5; Q96E73; Q9BQ63; B4DGW7; B4DM99
• Molecular Weight: 21,142 Da
• NCBI Official Full Name: nucleoside diphosphate kinase 6
• NCBI Official Synonym Full Names: non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
• NCBI Official Symbol: NME6
• NCBI Official Synonym Symbols: NDK 6; NM23-H6; IPIA-ALPHA
• NCBI Protein Information: nucleoside diphosphate kinase 6; NDP kinase 6; OTTHUMP00000164810; OTTHUMP00000210736; OTTHUMP00000210737; OTTHUMP00000210738; OTTHUMP00000210741; OTTHUMP00000210742; OTTHUMP00000210744; OTTHUMP00000210745; inhibitor of p53-induced apoptosis-alpha
• UniProt Protein Name: Nucleoside diphosphate kinase 6
• Protein Family: Nucleoside diphosphate kinase
• UniProt Gene Name: NME6
• UniProt Entry Name: NDK6_HUMAN

NCBI Description

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM]

Uniprot Description

NME6: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis. Belongs to the NDK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 2.7.4.6; Kinase, other; Kinase, nucleoside diphosphate; Other group; NDK family

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: mitochondrion

Molecular Function: metal ion binding; nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; CTP biosynthetic process; apoptosis; UTP biosynthetic process; negative regulation of mitosis; nucleoside diphosphate phosphorylation; negative regulation of cell growth