Tissue Factor Pathway Inhibitor 2 Active Protein | TFPI2 active protein
Recombinant Human Tissue Factor Pathway Inhibitor 2
Gene Names
TFPI2; PP5; REF1; TFPI-2
Purity
Greater than 97.0% as determined by SDS-PAGE.
Synonyms
Tissue Factor Pathway Inhibitor 2; Recombinant Human Tissue Factor Pathway Inhibitor 2; TFPI2 Human; Tissue Factor Pathway Inhibitor 2 Human Recombinant; TFPI-2; REF1; Placental protein 52; TFPI2 active protein
Host
Nicotiana benthamiana
Purity/Purification
Greater than 97.0% as determined by SDS-PAGE.
Form/Format
Lyophilized from a concentrated (1mg/ml) solution containing PBS pH-7.1.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
DAAQEPTGNN AEICLLPLDY GPCRALLLRY YYDRYTQSCR QFLYGGCEGN ANNFYTWEAC DDACWRIEKV PKVCRLQVSV DDQCEGSTEK YFFNLSSMTC EKFFSGGCHR NRIENRFPDE ATCMGFCAPK KIPSFCYSPK DEGLCSANVT RYYFNPRYRT CDAFTYTGCG GNDNNFVSRE DCKRACAKAL KLEHHHHHH
Sequence Length
224
Solubility
It is recommended to reconstitute the lyophilized TFPI2 in sterile water & 50ug/ml BSA at a concentration of 1mg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The activity of the TFPI2 is expressed as the amount of trypsin inhibited per milligram of TFPI2. The ability to prevent the hydrolysis of benzoyl-Larginine ethyl ester hydrochloride by trypsin is measured by spectrophotometer. 1mg TFPI2 protein will inhibit 1-1.5 mg trypsin with activity of approximately 10,000 BAEE units per mg protein.
Preparation and Storage
Lyophilized TFPI2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution TFPI2 Human should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for TFPI2 active protein
Description: TFPI2 Human Recombinant produced in plants is a single polypeptide chain containing 79 amino acids and having a total molecular mass of 9.3kDa. The TFPI2 is fused to 6xHis Tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction: TFPI2 takes part in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 doesn't have any influence on thrombin.
Introduction: TFPI2 takes part in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 doesn't have any influence on thrombin.
Product Categories/Family for TFPI2 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,796 Da
NCBI Official Full Name
tissue factor pathway inhibitor 2 isoform 2
NCBI Official Synonym Full Names
tissue factor pathway inhibitor 2
NCBI Official Symbol
TFPI2
NCBI Official Synonym Symbols
PP5; REF1; TFPI-2
NCBI Protein Information
tissue factor pathway inhibitor 2; placental protein 5; retinal pigment epithelium cell factor 1
UniProt Protein Name
Tissue factor pathway inhibitor 2
Protein Family
UniProt Gene Name
TFPI2
UniProt Synonym Gene Names
TFPI-2; PP5
UniProt Entry Name
TFPI2_HUMAN
NCBI Description
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Description
TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: proteinaceous extracellular matrix; nucleus
Molecular Function: serine-type endopeptidase inhibitor activity; extracellular matrix structural constituent
Biological Process: blood coagulation
Research Articles on TFPI2
Similar Products
Product Notes
The TFPI2 tfpi2 (Catalog #AAA144146) is an Active Protein produced from Nicotiana benthamiana and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: DAAQEPTGNN AEICLLPLDY GPCRALLLRY YYDRYTQSCR QFLYGGCEGN ANNFYTWEAC DDACWRIEKV PKVCRLQVSV DDQCEGSTEK YFFNLSSMTC EKFFSGGCHR NRIENRFPDE ATCMGFCAPK KIPSFCYSPK DEGLCSANVT RYYFNPRYRT CDAFTYTGCG GNDNNFVSRE DCKRACAKAL KLEHHHH HH. It is sometimes possible for the material contained within the vial of "Tissue Factor Pathway Inhibitor 2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
