Rat NHL repeat containing 1 ELISA Kit | NHLRC1 elisa kit
Rat E3 ubiquitin-protein ligase NHLRC1, NHLRC1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
human homolog is a putative E3 ubiquitin ligase associated with Lafora progressive myoclonus epilepsy and possibly involved in clearance of polyglucosans from dendrites [RGD, Feb 2006]
Uniprot Description
Function: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway
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Product Notes
The Rat NHLRC1 nhlrc1 (Catalog #AAA9335044) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335044 ELISA Kit recognizes Rat NHLRC1. It is sometimes possible for the material contained within the vial of "NHL repeat containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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