Rat neurogenic differentiation 1 ELISA Kit | NEUROD1 elisa kit
Rat Neurogenic differentiation factor 1, NEUROD1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
a transcription factor; involved in neuronal differentiation [RGD, Feb 2006]
Uniprot Description
NEUROD1: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulates transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor p21Cip1. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2.
Protein type: DNA-binding; Transcription factor
Cellular Component: cytoplasm; intracellular; nucleus
Molecular Function: DNA binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; transcription coactivator activity; chromatin binding; transcription factor activity; transcription factor binding
Biological Process: response to drug; transcription from RNA polymerase II promoter; cell fate commitment; camera-type eye development; dentate gyrus development; transcription, DNA-dependent; regulation of neuron differentiation; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; nucleocytoplasmic transport; glucose homeostasis; endocrine pancreas development; anterior/posterior pattern formation; embryonic organ morphogenesis; insulin secretion; response to glucose stimulus; cerebellum development; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; positive regulation of neuron differentiation; nitric oxide mediated signal transduction; inner ear development; negative regulation of JAK-STAT cascade; hindbrain development
Research Articles on NEUROD1
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Product Notes
The Rat NEUROD1 neurod1 (Catalog #AAA9341341) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341341 ELISA Kit recognizes Rat NEUROD1. It is sometimes possible for the material contained within the vial of "neurogenic differentiation 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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